(S)-(+)-Piperidine-3-carboxylic acid
(S)-(+)-Nipecotic acid
CAS: 59045-82-8
Molecular Formula: C6H11NO2
(S)-(+)-Piperidine-3-carboxylic acid - Names and Identifiers
(S)-(+)-Piperidine-3-carboxylic acid - Physico-chemical Properties
| Molecular Formula | C6H11NO2 |
| Molar Mass | 129.16 |
| Density | 1.125±0.06 g/cm3(Predicted) |
| Melting Point | 254°C (dec.) |
| Boling Point | 265.8±33.0 °C(Predicted) |
| Appearance | Powder |
| Color | White |
| pKa | 3.88±0.20(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Refractive Index | 4.5 ° (C=5, H2O) |
| MDL | MFCD01630807 |
(S)-(+)-Piperidine-3-carboxylic acid - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29339900 |
(S)-(+)-Piperidine-3-carboxylic acid - Introduction
(S)-(+)-Nipecotic acid is an organic compound with a chemical formula of C6H9NO2 and a molecular weight of 135.14. It is a chiral molecule, and its stereo configuration is determined by a stereo center in the molecule, which is usually represented by the (S)-symbol.
(S)-( )-Nipecotic acid is a white crystalline solid under normal temperature and pressure, soluble in water and some organic solvents, such as ethanol and ether. It is weakly acidic and can react with bases to form the corresponding salts. Its melting point is about 179-182°C.
This compound has some important applications. First, it is a GABA transporter inhibitor, which can enhance the inhibitory effect of the nervous system by inhibiting the recovery of the neurotransmitter GABA. Therefore, it is used in the medical field as a precursor of antiepileptic and anxiolytic drugs.
Regarding the preparation method, a commonly used method is to obtain (S)-( )-Nipecotic acid by reacting 1-piperidinemethanol with chloroacetic acid. Other solvents and catalysts may also be used in the specific preparation process.
When using (S)-( )-Nipecotic acid, you need to pay attention to its security information. It may have an irritating effect on the skin, eyes and respiratory system, so appropriate personal protective measures should be taken, such as wearing gloves and goggles. During operation, good ventilation conditions should be ensured. At the same time, avoid contact with combustibles and oxidants to prevent fire or explosion. If contact or inhalation occurs, seek medical help immediately. Note Follow laboratory safety practices when handling (S)-( )-Nipecotic acid.
(S)-( )-Nipecotic acid is a white crystalline solid under normal temperature and pressure, soluble in water and some organic solvents, such as ethanol and ether. It is weakly acidic and can react with bases to form the corresponding salts. Its melting point is about 179-182°C.
This compound has some important applications. First, it is a GABA transporter inhibitor, which can enhance the inhibitory effect of the nervous system by inhibiting the recovery of the neurotransmitter GABA. Therefore, it is used in the medical field as a precursor of antiepileptic and anxiolytic drugs.
Regarding the preparation method, a commonly used method is to obtain (S)-( )-Nipecotic acid by reacting 1-piperidinemethanol with chloroacetic acid. Other solvents and catalysts may also be used in the specific preparation process.
When using (S)-( )-Nipecotic acid, you need to pay attention to its security information. It may have an irritating effect on the skin, eyes and respiratory system, so appropriate personal protective measures should be taken, such as wearing gloves and goggles. During operation, good ventilation conditions should be ensured. At the same time, avoid contact with combustibles and oxidants to prevent fire or explosion. If contact or inhalation occurs, seek medical help immediately. Note Follow laboratory safety practices when handling (S)-( )-Nipecotic acid.
Last Update：2024-04-09 21:49:45
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